论文-Laboratory of Immunology, Nucleic Acid Nanomedicine & Gene therapy

2026

Zhai Dongqing, Ni Jiaping, Shao Xianyu, Zhao Weijun, Chen Yuenan, Fan Kailin, Li Jintong, Shen Yumeng, Lin Ang#, Hu Weiwei#, Yang Yong#. Lipid nanoparticle-delivered ornithine transcarbamylase mRNA alleviates liver fibrosis in preclinical models.

Hepatology. 2026. online (# Co-corresponding authors)

2026

Kun Guo, Lijing Liu, Mingyun Shen, Karin Loré, Ang Lin. mRNA Vaccination for Treating Allergy by Modulating Allergen‐Specific Immunity.

iLABMED. 2026.

2025

李靖欣、马霄、林昂、潘红星、郝擘、邵娟、李月竹、许阳婷、邵祝军、徐爱强。多糖结合疫苗载体蛋白的研发与应用。

中华预防医学杂志，2025.

2025

Xi Li, Xianyu Shao, Xiangzheng Li, Qingqing Chen, Yu Zang, Jingyi Wang, Yong Yang, Lei Qiang, Ang Lin#, Yuan He#. Novel TNF-α-Targeting mRNA Therapy for Sustained Psoriasis Treatment and Relapse Prevention by Suppressing IL-15-TRM Signaling.

Journal of Controlled Release, 2025. PMID: 40935068. (# Co-corresponding authors)

2025

Kun Guo, Lingling Bu, Jintong Du, Wei Zhang, Jiayuan Xia, Mengmeng Tao, Xianyu Shao, Lijing Liu, Weijun Zhao, Yunsong Cai, Yong Yang, Xuben Hou, Ang Lin. A Novel Ionizable Lipid with Comprehensive Improvements in Transfection Potency, Immune Profile and Safety of Lipid Nanoparticle.

Journal of Controlled Release, 2025. PMID: 40818720.

2025

Narh Philip Amor, Kun Guo, Shun Zhang, Jun Xia, Yong Yang, Ang Lin. Lipid Nanoparticle: Beyond Delivery Vehicle—Unveiling Its Immunological Adjuvant Potential.

The FASEB J. 2025. PMID: 40372384.

2025

Xianyu Shao, Lijing Liu, Changzhen Weng, Kun Guo, Zhutao Lu, Lulu Huang, Zhenhua Di, Yixuan Guo, Guorong Di, Renmei Qiao, Jingyi Wang, Yong Yang, Shiyu Sun, Shentian Zhuang, Ang Lin. Leveraging an mRNA Platform for the Development of Vaccines Against Egg Allergy.

Vaccines (Basel), 2025. PMID: 40432060.

2024

Lulu Huang, Shun Zhang, Tongyi Zhao, Ting Cai, Lingling Bu, Zhenhua Di, Yujie Zhang, Chen Yang, Yong Yang, Ang Lin. Rational optimization of glycoprotein E (gE)-encoding mRNA for improved Varicella-zoster virus mRNA vaccine development.

Emerging Microbes & Infections. 2024. PMID: 39137287.

2024

Lulu Huang, Tongyi Zhao, Weijun Zhao, Andong Shao, Huajun Zhao, ... Changzhen Weng, Lingling Bu, Zhenhua Di, Shiyu Sun, Qinsheng Dai, Minhui Sun, Limei Wang, Zhenguang Liu, Leilei Shi, Jiesen Hu, Shentong Fang, Cheng Zhang, Jian Zhang, Guan Wang, Karin Loré, Yong Yang, Ang Lin. Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques.

Emerging Microbes & Infections. 2024. PMID: 39137287.

2024

Chuanjiang Jian, Minjia Wang, Yunyun Qian, Xuejiao Song, Li Wang, Ling Li, Lulu Huang, Guan Wang, Xianjie Shi, Jinqiao Dong, Hao Li, Ang Lin#, Leilei Shi#. A TLR4‐Targeting Bioactive Peptide Hydrogel to Regulate Immune‐Microenvironment for Diabetic Wound Repair.

Advanced Healthcare Materials. 2024. PMID: 38568683

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